Likelihood and density modification

• Tom Terwilliger:

  • treat histogram as prior probability of density values
    • protein and solvent separately
  • treat average from other copies as prior probability
  • treat mask as probability of being in region governed by NCS operation

• Other possibilities:

  • develop likelihood function based on “molecular replacement equation”
  • develop likelihood function based on joint probability distribution of structure factors

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© 1999-2005 Randy J Read, University of Cambridge. All rights reserved.

Last updated: 7 June, 2005