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β-lactamase –β-lactamase inhibitor

Molecular Replacement

This example is illustrative of the case where one component of the asymmetric unit is easy to find in isolation and another is difficult or impossible to find. Knowledge of the partial structure of the component that is easy to find enables the complex to be easily built up by addition.

ROP four-helix bundle

Molecular Replacement

This example is illustrative of the case where there are multiple components of the asymmetric unit and a poor signal for each component in isolation. The correct solution for placing the first few components was only found after placing the last component.